End of the year thoughts - scientific philanthropy and impact

As we head into 2025, and the prospects for increased (US) government investment in science, engineering, and STEM education seem very limited, I wanted to revisit a topic that I wrote about over a decade ago (!!!), the role of philanthropy and foundations in these areas.  

Personally I think the case for government support of scientific research and education is overwhelmingly clear; while companies depend on having an educated technical workforce (at least for now) and continually improving technology, they are under great short-term financial pressures and genuinely long-term investment in research is rare.  Foundations are not a substitute for nation-state levels of support, but they are a critical component of the research and education landscape.  

Annual citations of the EPR paper from Web of Science,

a case study in the long-term impact of some "pure" scientific

research, and giving hope to practicing scientists that surely

our groundbreaking work will be appreciated sixty years 

after publication.  

A key question I've wondered about for a long time is how to properly judge the impact that research-supporting foundations are making.  The Science Philanthropy Alliance is a great organization that considers these issues deeply.

The nature of long-term research is that it often takes a long time for its true impact (I don't mean just citation counts, but those are an indicator of activity) to be felt.  One (admittedly extreme) example is shown here, the citations-per-year (from Web of Science) of the 1935 Einstein/Podolsky/Rosen paper about entanglement.  (Side note:  You have to love the provocative title, "Can Quantum-Mechanical Description of Physical Reality Be Considered Complete?", which from the point of view of the authors at the time satisfies Betteridge's Law of Headlines.)  There are few companies that would be willing to invest in supporting research that won't have its true heyday for five or six decades.

One additional tricky bit is that grants are usually given to people and organizations who are already active.  It's often not simple to point to some clear result or change in output that absolutely would not have happened without foundation support.  This is exacerbated by the fact that grants in science and engineering are often given to people and organizations who are not just active but already very well supported - betting on an odds-on favorite is a low risk strategy. 

Many foundations do think very carefully about what areas to support, because they want to "move the needle".  For example, some scientific foundations are consciously reluctant to support closer-to-clinical-stage cancer research, since the total annual investment by governments and pharmaceutical companies in that area numbers in the many billions of dollars, and a modest foundation contribution would be a tiny delta on top of that.  

Here is a list of the wealthiest charitable foundations (only a few of which support scientific research and/or education) and their endowments.  Nearly all of the science-related ones are also plugged in here.  A rough estimate of annual expenditures from endowed entities is about 5% of their holdings.  Recently I've come to think about private universities as one crude comparator for impact.  If a foundation has the same size endowment as a prestigious research university, I think it's worth thinking about the relative downstream impacts of those entities.  (Novo Nordisk Foundation has an endowment three times the size of Harvard's endowment.)  

Another comparator would be the annual research expenditures of a relevant funding agency.  The US NSF put forward $234M into major research instrumentation and facilities in FY2024.  A foundation with a $5B endowment could in principle support all of that from endowment returns.  This lets me make my semiregular pitch about foundational or corporate support for research infrastructure and user facilities around the US.  The entire annual budget for the NSF's NNCI, which supports shared nanofabrication and characterization facilities around the US, is about $16M.   That's a niche where comparatively modest foundation (or corporate) support could have serious impact for interdisciplinary research and education across the country.  I'm sure there are other similar areas out there, and I hope someone is thinking about this.  

Anyway, thanks to my readers - this is now the 20th year of this blog's existence (!!! again), and I hope to be able to keep it up well in the new year.