So you want to build a science/engineering laboratory building

A very quick summary of some non-negative news developments:

• The NSF awarded 500 more graduate fellowships this week, bringing the total for this year up to 1500.  (Apologies for the X link.)  This is still 25% lower than last year's number, and of course far below the original CHIPS and Science act target of 3000, but it's better than the alternative.  I think we can now all agree that the supposed large-scale bipartisan support for the CHIPS and Science act was illusory.
• There seems to be some initial signs of pushback on the senate side regarding the proposed massive science funding cuts.  Again, now is the time to make views known to legislators - I am told by multiple people with experience in this arena that it really can matter.
• There was a statement earlier this week that apparently the US won't be going after Chinese student visas.  This would carry more weight if it didn't look like US leadership was wandering ergodically through all possible things to say with no actual plan or memory.

On to the main topic of this post.  Thanks to my professional age (older than dirt) and my experience (overseeing shared research infrastructure; being involved in a couple of building design and construction projects; and working on PI lab designs and build-outs), I have some key advice and lessons learned for anyone designing a new big science/engineering research building.  This list is by no means complete, and I invite readers to add their insights in the comments.  While it seems likely that many universities will be curtailing big capital construction projects in the near term because of financial uncertainty, I hope this may still come in handy to someone.  

• Any big laboratory building should have a dedicated loading dock with central receiving.  If you're spending $100M-200M on a building, this is not something that you should "value engineer" away.  The long term goal is a building that operates well for the PIs and is easy to maintain, and you're going to need to be able to bring in big crates for lab and service equipment.  You should have a freight elevator adjacent to the dock.  
• You should also think hard about what kind of equipment will have to be moved in and out of the building when designing hallways, floor layouts, and door widths.  You don't want to have to take out walls, doorframes, or windows, or to need a crane to hoist equipment into upper floors because it can't get around corners.
• Think hard about process gasses and storage tanks at the beginning.  Will PIs need to have gas cylinders and liquid nitrogen and argon tanks brought in and out in high volumes all the time, with all the attendant safety concerns?  Would you be better off getting LN2 or LAr tanks even though campus architects will say they are unsightly?  
• Likewise, consider whether you should have building-wide service for "lab vacuum", N2 gas, compressed air, DI water, etc.  If not and PIs have those needs, you should plan ahead to deal with this.
• Gas cylinder and chemical storage - do you have enough on-site storage space for empty cylinders and back-up supply cylinders?  If this is a very chemistry-heavy building, think hard about safety and storing solvents. 
• Make sure you design for adequate exhaust capacity for fume hoods.  Someone will always want to add more hoods.  While all things are possible with huge expenditures, it's better to make sure you have capacity to spare, because adding hoods beyond the initial capacity would likely require a huge redo of the building HVAC systems.
• Speaking of HVAC, think really hard about controls and monitoring.  Are you going to have labs that need tight requirements on temperature and humidity?  When you set these up, put have enough sensors of the right types in the right places, and make sure that your system is designed to work even when the outside air conditions are at their seasonal extremes (hot and humid in the summer, cold and dry in the winter).  Also, consider having a vestibule (air lock) for the main building entrance - you'd rather not scoop a bunch of hot, humid air (or freezing, super-dry air) into the building every time a student opens the door.
• Still on HVAC, make sure that power outages and restarts don't lead to weird situations like having the whole building at negative pressure relative to the outside, or duct work bulging or collapsing.
• Still on HVAC, actually think about where the condensate drains for the fan units will overflow if they get plugged up or overwhelmed.  You really don't want water spilling all over a rack of networking equipment in an IT closet.  Trust me.
• Chilled water:  Whether it's the process chilled water for the air conditioning, or the secondary chilled water for lab equipment, make sure that the loop is built correctly.   Incompatible metals (e.g., some genius throws in a cast iron fitting somewhere, or joints between dissimilar metals) can lead to years and years of problems down the line.  Make sure lines are flushed and monitored for cleanliness, and have filters in each lab that can be checked and maintained easily.
• Electrical - design with future needs in mind.  If possible, it's a good idea to have PI labs with their own isolation transformers, to try to mitigate inter-lab electrical noise issues.  Make sure your electrical contractors understand the idea of having "clean" vs. "dirty" power and can set up the grounding accordingly while still being in code.
• Still on electrical, consider building-wide surge protection, and think about emergency power capacity.  For those who don't know, emergency power is usually a motor-generator that kicks in after a few seconds to make sure that emergency lighting and critical systems (including lab exhaust) keep going.
• Ceiling heights, duct work, etc. - It's not unusual for some PIs to have tall pieces of equipment.  Think about how you will accommodate these.  Pits in the floors of basement labs?  5 meter slab-to-slab spacing?  Think also about how ductwork and conduits are routed.  You don't want someone to tell you that installation of a new apparatus is going to cost a bonus $100K because shifting a duct sideways by half a meter will require a complete HVAC redesign.
• Think about the balance between lab space and office space/student seating.  No one likes giant cubicle farm student seating, but it does have capacity.  In these days of zoom and remote access to experiments, the way students and postdocs use offices is evolving, which makes planning difficult.  Health and safety folks would definitely prefer not to have personnel effectively headquartered directly in lab spaces.  Seriously, though, when programming a building, you need to think about how many people per PI lab space will need places to sit.  I have yet to see a building initially designed with enough seating to handle all the personnel needs if every PI lab were fully occupied and at a high level of research activity. 
• Think about maintenance down the line.  Every major building system has some lifespan.  If a big air handler fails, is it accessible and serviceable, or would that require taking out walls or cutting equipment into pieces and disrupting the entire building?  Do you want to set up a situation where you may have to do this every decade?  (Asking for a friend.)
• Entering the realm of fantasy, use your vast power and influence to get your organization to emphasize preventative maintenance at an appropriate level, consistently over the years.  Universities (and national labs and industrial labs) love "deferred maintenance" because kicking the can down the road can make a possible cost issue now into someone else's problem later.  Saving money in the short term can be very tempting.  It's also often easier and more glamorous to raise money for the new J. Smith Laboratory for Physical Sciences than it is to raise money to replace the HVAC system in the old D. Jones Engineering Building.  Avoid this temptation, or one day (inevitably when times are tight) your university will notice that it has $300M in deferred maintenance needs.

I may update this list as more items occur to me, but please feel free to add input/ideas.